Research in the Sheffield lab
Nathan Sheffield, PhD
We develop and apply computational methods
to organize, analyze, and understand large epigenomic data.
Each cell's genome is the same
...yet the cells are diverse
How can one set of instructions
give rise to a multicellular being?
In development, cells differentiate into roles...
...by folding DNA differently to use a different subset.
...but when it breaks down, disease can result
We can measure DNA folding by sequencing
But huge, diverse datasets lead to computational challenges.
Large-scale metadata standardization
Augmented Interval List
Coordinate Covariation Analysis
Analysis of DNA methylation in Ewing sarcoma
Thanks for listening!